Analyzing the genes related to Alzheimer's disease via a network and pathway-based approach.

ABSTRACT:

Background

Our understanding of the molecular mechanisms underlying Alzheimer's disease (AD) remains incomplete. Previous studies have revealed that genetic factors provide a significant contribution to the pathogenesis and development of AD. In the past years, numerous genes implicated in this disease have been identified via genetic association studies on candidate genes or at the genome-wide level. However, in many cases, the roles of these genes and their interactions in AD are still unclear. A comprehensive and systematic analysis focusing on the biological function and interactions of these genes in the context of AD will therefore provide valuable insights to understand the molecular features of the disease.

Method

In this study, we collected genes potentially associa

SUBMITTER: Hu YS 

PROVIDER: S-EPMC5406904 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature