Proximal methylation features associated with nonrandom changes in gene body methylation.

ABSTRACT:

Background

Gene body methylation at CG dinucleotides is a widely conserved feature of methylated genomes but remains poorly understood. The Arabidopsis thaliana strain Cvi has depleted gene body methylation relative to the reference strain Col. Here, we leverage this natural epigenetic difference to investigate gene body methylation stability.

Results

Recombinant inbred lines derived from Col and Cvi were used to examine the transmission of distinct gene body methylation states. The vast majority of genic CG methylation patterns are faithfully transmitted over nine generations according to parental genotype, with only 1-4% of CGs either losing or gaining methylation relative to the parent. Genic CGs that fail to maintain the parental methylation state are shared among indepe

SUBMITTER: Picard CL 

PROVIDER: S-EPMC5406939 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature