Expression of the Plasmodium falciparum Clonally Variant clag3 Genes in Human Infections.

ABSTRACT:

Background

Many genes of the malaria parasite Plasmodium falciparum show clonally variant expression regulated at the epigenetic level. These genes participate in fundamental host-parasite interactions and contribute to adaptive processes. However, little is known about their expression patterns during human infections. A peculiar case of clonally variant genes are the 2 nearly identical clag3 genes, clag3.1 and clag3.2, which mediate nutrient uptake and are linked to resistance to some toxic compounds.

Methods

We developed a procedure to characterize the expression of clag3 genes in naturally infected patients and in experimentally infected human volunteers.

Results

We provide the first description of clag3 expression during human infections, which revealed mutually

SUBMITTER: Mira-Martinez S 

PROVIDER: S-EPMC5407054 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature