Global brain asymmetry is increased in schizophrenia and related to avolition.

ABSTRACT:

Objective

Schizophrenia may be the result of a failure of the normal lateralization process of the brain. However, whole-brain asymmetry has not been assessed up to date. Here, we propose a novel measure of global brain asymmetry based on the Dice coefficient to quantify similarity between brain hemispheres.

Method

Global gray and white matter asymmetry was calculated from high-resolution T1 structural images acquired from 24 patients with schizophrenia and 26 healthy controls, age- and sex-matched. Some of the analyses were replicated in a much larger sample (n = 759) obtained from open-access online databases.

Results

Patients with schizophrenia had more global gray matter asymmetry than controls. Additionally, increased gray matter asymmetry was associated with avo

SUBMITTER: Nunez C 

PROVIDER: S-EPMC5407086 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature