Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis.

ABSTRACT:

Background

To assess the worldwide variation of amyotrophic lateral sclerosis (ALS) incidence, we performed a systematic review and meta-analysis of population-based data published to date.

Methods

We reviewed Medline and Embase up to June 2015 and included all population-based studies of newly diagnosed ALS cases, using multiple sources for case ascertainment. ALS crude and standardized incidence (on age and sex using the US 2010 population) were calculated. Random effect meta-analysis and meta-regression were performed using the subcontinent as the main study level covariate. Sources of heterogeneity related to the characteristics of the study population and the study methodology were investigated.

Results

Among 3216 records, 44 studies were selected, covering 45 ge

SUBMITTER: Marin B 

PROVIDER: S-EPMC5407171 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature