Systematic correlation of environmental exposure and physiological and self-reported behaviour factors with leukocyte telomere length.

ABSTRACT:

Background

It is hypothesized that environmental exposures and behaviour influence telomere length, an indicator of cellular ageing. We systematically associated 461 indicators of environmental exposures, physiology and self-reported behaviour with telomere length in data from the US National Health and Nutrition Examination Survey (NHANES) in 1999-2002. Further, we tested whether factors identified in the NHANES participants are also correlated with gene expression of telomere length modifying genes.

Methods

We correlated 461 environmental exposures, behaviours and clinical variables with telomere length, using survey-weighted linear regression, adjusting for sex, age, age squared, race/ethnicity, poverty level, education and born outside the USA, and estimated the false di

SUBMITTER: Patel CJ 

PROVIDER: S-EPMC5407176 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature