Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors.

ABSTRACT: Mammalian tissues rely on a variety of nutrients to support their physiological functions. It is known that altered metabolism is involved in the pathogenesis of cancer, but which nutrients support the inappropriate growth of intact malignant tumors is incompletely understood. Amino acids are essential nutrients for many cancer cells that can be obtained through the scavenging and catabolism of extracellular protein via macropinocytosis. In particular, macropinocytosis can be a nutrient source for pancreatic cancer cells, but it is not fully understood how the tumor environment influences metabolic phenotypes and whether macropinocytosis supports the maintenance of amino acid levels within pancreatic tumors. Here we utilize miniaturized plasma exchange to deliver labeled albumin to tissues

SUBMITTER: Davidson SM 

PROVIDER: S-EPMC5407288 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature