Sex differences in the association of cutaneous melanoma incidence rates and geographic ultraviolet light exposure.

ABSTRACT:

Background

Cutaneous melanoma (CM) incidence rates continue to increase, and the reasons are unknown. Previously, we reported a unique age-specific sex difference in melanoma that suggested additional causes other than solar ultraviolet (UV) radiation.

Objective

This study attempted to understand whether and how UV radiation differentially impacts the CM incidence in men and women.

Methods

CM data and daily UV index (UVI) from 31 cancer registries were collected for association analysis. A second dataset from 42 US states was used for validation.

Results

There was no association between log-transformed female CM rates and levels of UVI, but there was a significant association between male rates and UVI and a significant association between overall rates and UVI

SUBMITTER: Liu-Smith F 

PROVIDER: S-EPMC5407289 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature