Oxidized LDL, Gamma-Glutamyltransferase and Adverse Outcomes in Older Adults.

ABSTRACT:

Objectives

Gamma-glutamyltransferase (GGT) is a biomarker of liver disease and oxidative stress which was associated with all-cause and cardiovascular (CV) mortality in the general population and in patients with high risk conditions. This study aims at assessing whether oxLDL modifies the relationship between GGT, all-cause, and CV mortality in elderly individuals from the general population.

Design

Observational longitudinal study.

Setting

Population-based cohort of older individuals (>65 years) free of liver disease.

Participants

One thousand and thirty-eight individuals from the Invecchiare in Chianti (InCHIANTI) study.

Measurements

Serum GGT level, oxidized low-density lipoprotein (oxLDL), CV comorbidities, all-cause and CV mortality.

Results

SUBMITTER: Spoto B 

PROVIDER: S-EPMC5407291 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature