Thrombocytopenia and extracorporeal membrane oxygenation in adults with acute respiratory failure: a cohort study.

ABSTRACT:

Purpose

The association between extracorporeal membrane oxygenation (ECMO) use and the development of thrombocytopenia is widely presumed yet weakly demonstrated. We hypothesized that longer duration of ECMO support would be independently associated with worsened thrombocytopenia.

Methods

We performed a single-center retrospective cohort study of 100 adults who received ECMO for acute respiratory failure. We used generalized estimating equations to test the association between days on ECMO and daily percentage of platelets compared to the first post-cannulation platelet count. We constructed a multivariable logistic regression model with backwards stepwise elimination to identify clinical predictors of severe thrombocytopenia (≤50,000/μL) while on ECMO.

Results

Days o

SUBMITTER: Abrams D 

PROVIDER: S-EPMC5407307 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature