Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder.

ABSTRACT:

Background

Bipolar affective disorder (BPD) is a severe mood disorder with a prevalence of ∼1.5% in the population. The pathogenesis of BPD is poorly understood; however, a strong heritable component has been identified. Previous genome-wide association studies have indicated a region on 6q25, coding for the SYNE1 gene, which increases disease susceptibility. SYNE1 encodes the synaptic nuclear envelope protein-1, nesprin-1. A brain-specific splice variant of SYNE1, CPG2 encoding candidate plasticity gene 2, has been identified. The intronic single-nucleotide polymorphism with the strongest genome-wide significant association in BPD, rs9371601, is present in both SYNE1 and CPG2.

Methods

We screened 937 BPD samples for genetic variation in SYNE1 exons 14-33, which covers the C

SUBMITTER: Sharp SI 

PROVIDER: S-EPMC5407451 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature