Determinants of non-adherence to disease-modifying therapies in multiple sclerosis: A cross-Canada prospective study.

ABSTRACT:

Background

Poor adherence to the disease-modifying therapies (DMTs) for multiple sclerosis (MS) may attenuate clinical benefit. A better understanding of characteristics associated with non-adherence could improve outcomes.

Objective

To evaluate characteristics associated with non-adherence to injectable DMTs.

Methods

Consecutive patients from four Canadian MS Clinics were assessed at three time points over two years. Clinical and demographic information included self-reported DMT use, missed doses in the previous 30 days, health behaviors, and comorbidities. Non-adherence was defined as <80% of expected doses taken. We employed generalized estimating equations to examine characteristics associated with non-adherence at all time points with findings reported as adjust

SUBMITTER: McKay KA 

PROVIDER: S-EPMC5407504 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature