Investigations of Glucocorticoid Action in GN.

ABSTRACT: For several decades, glucocorticoids have been used empirically to treat rapid progressive GN. It is commonly assumed that glucocorticoids act primarily by dampening the immune response, but the mechanisms remain incompletely understood. In this study, we inactivated the glucocorticoid receptor (GR) specifically in kidney epithelial cells using Pax8-Cre/GR^fl/fl mice. Pax8-Cre/GR^fl/fl mice did not exhibit an overt spontaneous phenotype. In mice treated with nephrotoxic serum to induce crescentic nephritis (rapidly progressive GN), this genetic inactivation of the GR in kidney epithelial cells exerted renal benefits, including inhibition of albuminuria and cellular crescent formation, similar to the renal benefits observed with high-dose prednisolone in control mice. Ho

SUBMITTER: Kuppe C 

PROVIDER: S-EPMC5407712 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature