NFκB-Induced Periostin Activates Integrin-β3 Signaling to Promote Renal Injury in GN.

ABSTRACT: De novo expression in the kidney of periostin, a protein involved in odontogenesis and osteogenesis, has been suggested as a biomarker of renal disease. In this study, we investigated the mechanism(s) of induction and the role of periostin in renal disease. Using a combination of bioinformatics, reporter assay, and chromatin immunoprecipitation analyses, we found that NFκB and other proinflammatory transcription factors induce periostin expression in vitro and that binding of these factors on the periostin promoter is enriched in glomeruli during experimental GN. Mice lacking expression of periostin displayed preserved renal function and structure during GN. Furthermore, delayed administration of periostin antisense oligonucleotides in wild-type animals with GN reverse

SUBMITTER: Prakoura N 

PROVIDER: S-EPMC5407726 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature