Blood type, ABO genetic variants, and ovarian cancer survival.

ABSTRACT:

Objective

Blood type A and the A1 allele have been associated with increased ovarian cancer risk. With only two small studies published to date, evidence for an association between ABO blood type and ovarian cancer survival is limited.

Methods

We conducted a retrospective cohort study of Tumor Registry confirmed ovarian cancer cases from the Vanderbilt University Medical Center with blood type from linked laboratory reports and ABO variants from linked Illumina Exome BeadChip data. Associations with overall survival (OS) were quantified by hazard ratios (HR) and confidence intervals (CI) from proportional hazards regression models; covariates included age, race, stage, grade, histologic subtype, and year of diagnosis.

Results

ABO phenotype (N = 694) and/or genotype (N

SUBMITTER: Cozzi GD 

PROVIDER: S-EPMC5407760 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature