Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis.

ABSTRACT:

Context

Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality.

Objectives

Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone.

Design

Bi-directional Mendelian randomization (MR) analysis on prospective cohorts.

Setting

Five cohorts from Denmark, Germany and Sweden (Inter99, SHIP, SHIP Trend, GOOD and MrOS Sweden).

Participants

7446 Caucasian men, genotyped for 97 BMI-associated SNPs and three testosterone-associated SNPs.

Main outcome measures

BMI and serum testosterone adjusted for age, smoking, time of blood sampling and site.

Results

1 SD genetically instrumented increase in BMI was associated with a 0.25 SD d

SUBMITTER: Eriksson J 

PROVIDER: S-EPMC5407807 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature