Emphysema is associated with thoracic vertebral bone attenuation on chest CT scan in HIV-infected individuals.

ABSTRACT:

Background

Age-related chronic diseases are prevalent in HIV-infected persons in the antiretroviral therapy (ART) era. Bone mineral density (BMD) loss and emphysema have separately been shown to occur at a younger age and with lesser risk exposure in HIV-infected compared to HIV-uninfected individuals. In non-HIV infected smokers, emphysema has been shown to independently predict low BMD. We hypothesized that emphysema would independently associate with thoracic vertebral bone attenuation, a surrogate for bone mineral density, in HIV-infected individuals.

Methods

Clinical, pulmonary function, and radiographic data were analyzed for 164 individuals from the University of Pittsburgh's HIV Lung Research Center cohort. Chest CT scans were used to quantify emphysema and compute H

SUBMITTER: Petraglia A 

PROVIDER: S-EPMC5407811 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature