Zika infection of neural progenitor cells perturbs transcription in neurodevelopmental pathways.

ABSTRACT:

Background

A recent study of the gene expression patterns of Zika virus (ZIKV) infected human neural progenitor cells (hNPCs) revealed transcriptional dysregulation and identified cell cycle-related pathways that are affected by infection. However deeper exploration of the information present in the RNA-Seq data can be used to further elucidate the manner in which Zika infection of hNPCs affects the transcriptome, refining pathway predictions and revealing isoform-specific dynamics.

Methodology/principal findings

We analyzed data published by Tang et al. using state-of-the-art tools for transcriptome analysis. By accounting for the experimental design and estimation of technical and inferential variance we were able to pinpoint Zika infection affected pathways that highlight

SUBMITTER: Yi L 

PROVIDER: S-EPMC5407828 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature