A longitudinal cline characterizes the genetic structure of human populations in the Tibetan plateau.

ABSTRACT: Indigenous populations of the Tibetan plateau have attracted much attention for their good performance at extreme high altitude. Most genetic studies of Tibetan adaptations have used genetic variation data at the genome scale, while genetic inferences about their demography and population structure are largely based on uniparental markers. To provide genome-wide information on population structure, we analyzed new and published data of 338 individuals from indigenous populations across the plateau in conjunction with worldwide genetic variation data. We found a clear signal of genetic stratification across the east-west axis within Tibetan samples. Samples from more eastern locations tend to have higher genetic affinity with lowland East Asians, which can be explained by more gene flow fro

SUBMITTER: Jeong C 

PROVIDER: S-EPMC5407838 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature