IL-15-deficient mice develop enhanced allergic responses to airway allergen exposure.

ABSTRACT:

Background

Interleukin-15 is a pleiotropic cytokine that is critical for the development and survival of multiple haematopoietic lineages. Mice lacking IL-15 have selective defects in populations of several pro-allergic immune cells including natural killer (NK) cells, NKT cells, and memory CD8⁺ T cells. We therefore hypothesized that IL-15^-/- mice will have reduced inflammatory responses during the development of allergic airway disease (AAD).

Objective

To determine whether IL-15^-/- mice have attenuated allergic responses in a mouse model of AAD.

Methods

C57BL/6 wild-type (WT) and IL-15^-/- mice were sensitized and challenged with ovalbumin (OVA), and the development of AAD was ascertained by examining changes in airway infl

SUBMITTER: Mathias CB 

PROVIDER: S-EPMC5407912 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature