Drosophila melanogaster as a High-Throughput Model for Host-Microbiota Interactions.

ABSTRACT: Microbiota research often assumes that differences in abundance and identity of microorganisms have unique influences on host physiology. To test this concept mechanistically, germ-free mice are colonized with microbial communities to assess causation. Due to the cost, infrastructure challenges, and time-consuming nature of germ-free mouse models, an alternative approach is needed to investigate host-microbial interactions. Drosophila melanogaster (fruit flies) can be used as a high throughput in vivo screening model of host-microbiome interactions as they are affordable, convenient, and replicable. D. melanogaster were essential in discovering components of the innate immune response to pathogens. However, axenic D. melanogaster can easily be generated for micr

SUBMITTER: Trinder M 

PROVIDER: S-EPMC5408076 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature