WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions.

ABSTRACT: There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed at improving therapeutic interventions do not take advantage of real-time in vivo neurochemical changes in dynamic brain processes such as disease progression and response to pharmacologic, cognitive, behavioral, and neuromodulation therapies. This is due in part to a lack of flexible research tools that allow in vivo measurement of the dynamic changes in brain chemistry. Here, we present a research platform, WINCS Harmoni, which can measure in vivo neurochemical activity simultaneously across multiple anatomical targets to study normal and pathologic brain function. In addition, WINCS Harmoni can provide real-time neurochemical feedb

SUBMITTER: Lee KH 

PROVIDER: S-EPMC5408229 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature