Preparation, Characterization and Properties of Alginate/Poly(γ-glutamic acid) Composite Microparticles.

ABSTRACT: Alginate (Alg) is a renewable polymer with excellent hemostatic properties and biocapability and is widely used for hemostatic wound dressing. However, the swelling properties of alginate-based wound dressings need to be promoted to meet the requirements of wider application. Poly(γ-glutamic acid) (PGA) is a natural polymer with high hydrophility. In the current study, novel Alg/PGA composite microparticles with double network structure were prepared by the emulsification/internal gelation method. It was found from the structure characterization that a double network structure was formed in the composite microparticles due to the ion chelation interaction between Ca2+ and the carboxylate groups of Alg and PGA and the electrostatic interaction between the secondary amine group of PGA and th

SUBMITTER: Tong Z 

PROVIDER: S-EPMC5408237 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature