Characterization and Potential Antitumor Activity of Polysaccharide from Gracilariopsis lemaneiformis.

ABSTRACT: Substances with valuable antitumor properties have been identified in many marine algae, including an edible polysaccharide from the marine alga Gracilariopsis lemaneiformis (PGL). We previously reported transcriptome profiling data showing that PGL induced transcriptional alterations generate anti-lung cancer activity. To identify how PGL is detrimental to tumors, we purified PGL to characterize its chemical composition, molecular weight, and sugar and protein content and investigated its antitumor activity. We demonstrated that PGL exerted its antitumor activities by modulating cell viability, morphology, apoptosis, and the apoptosis-related Fas/FasL signaling pathway in the human lung cancer cell line A549, the gastric cancer cell line MKN28, and the mouse melanoma cell line B16. Our da

SUBMITTER: Kang Y 

PROVIDER: S-EPMC5408246 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature