Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome.

ABSTRACT:

Background

Salmonella is one of the most significant food-borne pathogens to affect humans and agriculture. While it is well documented that Salmonella infection triggers host inflammation, the impacts on the gut environment are largely unknown. A CBA/J mouse model was used to evaluate intestinal responses to Salmonella-induced inflammation. In parallel, we evaluated chemically induced inflammation by dextran sodium sulfate (DSS) and a non-inflammation control. We profiled gut microbial diversity by sequencing 16S ribosomal ribonucleic acid (rRNA) genes from fecal and cecal samples. These data were correlated to the inflammation marker lipocalin-2 and short-chain fatty acid concentrations.

Results

We demonstrated that inflammation, chemically or biologically induced, restruc

SUBMITTER: Borton MA 

PROVIDER: S-EPMC5408407 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature