PDB2CD: a web-based application for the generation of circular dichroism spectra from protein atomic coordinates.

ABSTRACT:

Motivation

Circular dichroism (CD) spectroscopy is extensively utilized for determining the percentages of secondary structure content present in proteins. However, although a large contributor, secondary structure is not the only factor that influences the shape and magnitude of the CD spectrum produced. Other structural features can make contributions so an entire protein structural conformation can give rise to a CD spectrum. There is a need for an application capable of generating protein CD spectra from atomic coordinates. However, no empirically derived method to do this currently exists.

Results

PDB2CD has been created as an empirical-based approach to the generation of protein CD spectra from atomic coordinates. The method utilizes a combination of structural feature

SUBMITTER: Mavridis L 

PROVIDER: S-EPMC5408769 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature