Wright-Fisher exact solver (WFES): scalable analysis of population genetic models without simulation or diffusion theory.

ABSTRACT:

Motivation

The simplifying assumptions that are used widely in theoretical population genetics may not always be appropriate for empirical population genetics. General computational approaches that do not require the assumptions of classical theory are therefore quite desirable. One such general approach is provided by the theory of absorbing Markov chains, which can be used to obtain exact results by directly analyzing population genetic Markov models, such as the classic bi-allelic Wright-Fisher model. Although these approaches are sometimes used, they are usually forgone in favor of simulation methods, due to the perception that they are too computationally burdensome. Here we show that, surprisingly, direct analysis of virtually any Markov chain model in population genetics can

SUBMITTER: Krukov I 

PROVIDER: S-EPMC5408789 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature