Combining multiple tools outperforms individual methods in gene set enrichment analyses.

ABSTRACT:

Motivation

Gene set enrichment (GSE) analysis allows researchers to efficiently extract biological insight from long lists of differentially expressed genes by interrogating them at a systems level. In recent years, there has been a proliferation of GSE analysis methods and hence it has become increasingly difficult for researchers to select an optimal GSE tool based on their particular dataset. Moreover, the majority of GSE analysis methods do not allow researchers to simultaneously compare gene set level results between multiple experimental conditions.

Results

The ensemble of genes set enrichment analyses (EGSEA) is a method developed for RNA-sequencing data that combines results from twelve algorithms and calculates collective gene set scores to improve the biological re

SUBMITTER: Alhamdoosh M 

PROVIDER: S-EPMC5408797 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature