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GENIUS: web server to predict local gene networks and key genes for biological functions.

ABSTRACT:

Summary

GENIUS is a user-friendly web server that uses a novel machine learning algorithm to infer functional gene networks focused on specific genes and experimental conditions that are relevant to biological functions of interest. These functions may have different levels of complexity, from specific biological processes to complex traits that involve several interacting processes. GENIUS also enriches the network with new genes related to the biological function of interest, with accuracies comparable to highly discriminative Support Vector Machine methods.

Availability and implementation

GENIUS currently supports eight model organisms and is freely available for public use at http://networks.bio.puc.cl/genius .

Contact

genius.psbl@gmail.com.

Supplementary information

Supplementary data are available at Bioinformatics online.

SUBMITTER: Puelma T

PROVIDER: S-EPMC5408817 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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GENIUS: web server to predict local gene networks and key genes for biological functions.

Puelma Tomas T Araus Viviana V Canales Javier J Vidal Elena A EA Cabello Juan M JM Soto Alvaro A Gutiérrez Rodrigo A RA

Bioinformatics (Oxford, England) 20170301 5

<h4>Summary</h4>GENIUS is a user-friendly web server that uses a novel machine learning algorithm to infer functional gene networks focused on specific genes and experimental conditions that are relevant to biological functions of interest. These functions may have different levels of complexity, from specific biological processes to complex traits that involve several interacting processes. GENIUS also enriches the network with new genes related to the biological function of interest, with accu ...[more]

PMID: 27993775

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