Lineage-Biased Stem Cells Maintain Estrogen-Receptor-Positive and -Negative Mouse Mammary Luminal Lineages.

ABSTRACT: Delineating the mammary differentiation hierarchy is important for the study of mammary gland development and tumorigenesis. Mammary luminal cells are considered a major origin of human breast cancers. However, how estrogen-receptor-positive (ER⁺) and ER^- luminal cells are developed and maintained remains poorly understood. The prevailing model suggests that a common stem/progenitor cell generates both cell types. Through genetic lineage tracing in mice, we find that SOX9-expressing cells specifically contribute to the development and maintenance of ER^- luminal cells and, to a lesser degree, basal cells. In parallel, PROM1-expressing cells give rise only to ER⁺ luminal cells. Both SOX9⁺ and PROM1⁺ cells specifically sustain

SUBMITTER: Wang C 

PROVIDER: S-EPMC5408864 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature