Genetic Variation in One-Carbon Metabolism and Changes in Metabolic Parameters in First-Episode Schizophrenia Patients.

ABSTRACT:

Background

In this study, we aimed to investigate the effects of polymorphisms in genes encoding 1-carbon metabolism enzymes on differential development of metabolic parameters during 12 weeks of treatment with second-generation antipsychotics in first-episode schizophrenia patients.

Methods

The following polymorphisms in 1-carbon metabolism genes were genotyped: MTHFR (C677T and A1298C), MTHFD1 (G1958A), MTRR (A66G), and BHMT (G742A). A broad panel of metabolic parameters including body mass index, waist circumference, total cholesterol low and high density lipoproteins, triglycerides, homocysteine, folate, and vitamin B12 was determined.

Results

There was a significant effect of the interaction between the MTHFR C677T polymorphism and time on body mass index and wai

SUBMITTER: Misiak B 

PROVIDER: S-EPMC5408968 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature