Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats.

ABSTRACT: Major depressive disorder is a serious mental disorder with high morbidity and mortality. The role of social stress in the development of depression remains unclear. Here, we used the social defeat stress paradigm to induce depression-like behavior in rats, then evaluated the behavior of the rats and measured metabolic changes in the prefrontal cortex using gas chromatography-mass spectrometry. Within the first week after the social defeat procedure, the sucrose preference test (SPT), open field test (OFT), elevated plus maze (EPM) and forced swim test (FST) were conducted to examine the depressive-like and anxiety-like behaviors. For our metabolite analysis, multivariate statistics were applied to observe the distribution of all samples and to differentiate the socially defeated group fro

SUBMITTER: Liu YY 

PROVIDER: S-EPMC5409051 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature