Feasibility of computerized working memory training in individuals with Huntington disease.

ABSTRACT:

Objectives

Huntington disease (HD) is associated with a variety of cognitive deficits, with prominent difficulties in working memory (WM). WM deficits are notably compromised in early-onset and prodromal HD patients. This study aimed to determine the feasibility of a computerized WM training program (Cogmed QM), novel to the HD population.

Methods

Nine patients, aged 26-62, with early stage HD underwent a 25-session (5 days/week for 5 weeks) WM training program (Cogmed QM). Training exercises involved the manipulation and storage of verbal and visuospatial information, with difficulty adapted as a function of individual performance. Neuropsychological testing was conducted before and after training, and performance on criterion WM measures (Digit Span and Spatial Span), near

SUBMITTER: Sadeghi M 

PROVIDER: S-EPMC5409057 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature