Complete elucidation of the late steps of bafilomycin biosynthesis in Streptomyces lohii.

ABSTRACT: Bafilomycins are an important subgroup of polyketides with diverse biological activities and possible applications as specific inhibitors of vacuolar H⁺-ATPase. However, the general toxicity and structural complexity of bafilomycins present formidable challenges to drug design via chemical modification, prompting interests in improving bafilomycin activities via biosynthetic approaches. Two bafilomycin biosynthetic gene clusters have been identified, but their post-polyketide synthase (PKS) tailoring steps for structural diversification and bioactivity improvement remain largely unknown. In this study, the post-PKS tailoring pathway from bafilomycin A₁ (1)→C₁ (2)→B₁ (3) in the marine microorganism Streptomyces lohii was elucidated for the

SUBMITTER: Li Z 

PROVIDER: S-EPMC5409476 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature