Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis.

ABSTRACT:

Objective

Few studies have assessed the association between leptin receptor (LEPR) gene polymorphism and the risk of cardiovascular disease (CVD). Of the few epidemiological studies on this topic, the results are still controversial.

Methods

PubMed and Embase were screened for studies from their inception to 9 October 2016. The pooled odds ratio (OR) with the corresponding confidence intervals (CI) were used to measure the effect size for studies that reported the association under allelic, homozygous, and dominant models. Pre-specified characteristics were conducted in the subgroup analysis. Heterogeneity between subgroups was evaluated by meta-regression analysis.

Results

Seven eligible studies involving 44,133 participants were included in our meta-analysis. Border

SUBMITTER: Wu L 

PROVIDER: S-EPMC5409576 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature