Diffusion tensor spectroscopic imaging of the human brain in children and adults.

ABSTRACT:

Purpose

We developed diffusion tensor spectroscopic imaging (DTSI), based on proton-echo-planar-spectroscopic imaging (PEPSI), and evaluated the feasibility of mapping brain metabolite diffusion in adults and children.

Methods

PRESS prelocalized DTSI at 3 Tesla (T) was performed using navigator-based correction of movement-related phase errors and cardiac gating with compensation for repetition time (TR) related variability in T₁ saturation. Mean diffusivity (MD) and fractional anisotropy (FA) of total N-acetyl-aspartate (tNAA), total creatine (tCr), and total choline (tCho) were measured in eight adults (17-60 years) and 10 children (3-24 months) using b_max  = 1734 s/mm² , 1 cc and 4.5 cc voxel sizes, with nominal scan times of 17 min and 8:

SUBMITTER: Fotso K 

PROVIDER: S-EPMC5409876 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature