Urinary Uromodulin and Risk of Urinary Tract Infections: The Cardiovascular Health Study.

ABSTRACT:

Background

Laboratory studies suggest that urinary uromodulin, the most common protein in the urine of healthy adults, may protect against urinary tract infection (UTI). Epidemiologic studies evaluating this relationship in humans are lacking.

Study design

Prospective longitudinal cohort study.

Setting & participants

953 participants enrolled in the Cardiovascular Health Study.

Predictor

Uromodulin assayed using enzyme-linked immunosorbent assay in spot urine samples.

Outcomes

Composite of outpatient UTI events or UTI-related hospitalizations and each of them individually identified using International Classification of Diseases, Ninth Revision (ICD-9) codes using negative binomial regression with robust standard errors adjusted for age, race, sex, body

SUBMITTER: Garimella PS 

PROVIDER: S-EPMC5409878 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature