Oxytetracycline induces DNA damage and epigenetic changes: a possible risk for human and animal health?

ABSTRACT:

Background

Oxytetracycline (OTC), which is largely employed in zootechnical and veterinary practices to ensure wellness of farmed animals, is partially absorbed within the gastrointestinal tract depositing in several tissues. Therefore, the potential OTC toxicity is relevant when considering the putative risk derived by the entry and accumulation of such drug in human and pet food chain supply. Despite scientific literature highlights several OTC-dependent toxic effects on human and animal health, the molecular mechanisms of such toxicity are still poorly understood.

Methods

Here, we evaluated DNA damages and epigenetic alterations by quantitative reverse transcription polymerase chain reaction, quantitative polymerase chain reaction, chromatin immuno-precipitation and Weste

SUBMITTER: Gallo A 

PROVIDER: S-EPMC5410137 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature