Whole genome sequencing of group A Streptococcus: development and evaluation of an automated pipeline for emmgene typing.

ABSTRACT: Streptococcus pyogenes group A Streptococcus (GAS) is the most common cause of bacterial throat infections, and can cause mild to severe skin and soft tissue infections, including impetigo, erysipelas, necrotizing fasciitis, as well as systemic and fatal infections including septicaemia and meningitis. Estimated annual incidence for invasive group A streptococcal infection (iGAS) in industrialised countries is approximately three per 100,000 per year. Typing is currently used in England and Wales to monitor bacterial strains of S. pyogenes causing invasive infections and those isolated from patients and healthcare/care workers in cluster and outbreak situations. Sequence analysis of the emm gene is the currently accepted gold standard methodology for GAS typing.

SUBMITTER: Kapatai G 

PROVIDER: S-EPMC5410157 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature