Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.

ABSTRACT: Tumor recurrence is usually detected within one year after radical resection of stage III gastric cancer. This study aimed to establish the expression profile and determine potential circular RNAs (circRNAs) and predict the early recurrence of stage III gastric cancer. We identified 46 differently expressed circRNAs between cancer and adjacent normal tissues through circRNA microarray. We further screened eight indicators related to early recurrence. We subsequently divided the remaining cases into two cohorts. qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort. We then constructed a four-circRNA-based classifier to evaluate the risk of early recurrence and distinguished patients with a high risk from

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5410275 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature