Genetic association of left ventricular mass assessed by M-mode and two-dimensional echocardiography.

ABSTRACT:

Background

Left ventricular mass offers prognostic information for assessing cardiovascular disease risk. M-mode and two-dimensional (2D) echocardiographically-derived left ventricular mass values have shown high accuracy and reproducibility; however, no studies to date have compared left ventricular mass genetic association findings on the basis of both the methods. The aim of this study was to compare associations of single-nucleotide polymorphisms (SNPs) from genome-wide association study analyses of left ventricular mass using both methods in the same cohort.

Methods and results

Left ventricular mass was determined using 2D and M-mode echocardiography in 711 patients (390 women); SNP genotype data were obtained using the Genome-wide Human SNP Array 6.0. Genome-wide assoc

SUBMITTER: Barve RA 

PROVIDER: S-EPMC5410384 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature