Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine.

ABSTRACT: Natural products have served as the main source of drugs and drug leads, and natural products produced by microorganisms are one of the most prevalent sources of clinical antibiotics. Their unparalleled structural and chemical diversities provide a basis to investigate fundamental biological processes while providing access to a tremendous amount of chemical space. There is a pressing need for novel antibiotics with new mode of actions to combat the growing challenge of multidrug resistant pathogens. This review begins with the pioneering discovery and biological activities of platensimycin (PTM) and platencin (PTN), two antibacterial natural products isolated from Streptomyces platensis. The elucidation of their unique biochemical mode of action, structure-activity relationships, and phar

SUBMITTER: Rudolf JD 

PROVIDER: S-EPMC5410400 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature