Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome.

ABSTRACT:

Background

Preclinical and clinical evidence supports the concept of bidirectional brain-gut microbiome interactions. We aimed to determine if subgroups of irritable bowel syndrome (IBS) subjects can be identified based on differences in gut microbial composition, and if there are correlations between gut microbial measures and structural brain signatures in IBS.

Methods

Behavioral measures, stool samples, and structural brain images were collected from 29 adult IBS and 23 healthy control subjects (HCs). 16S ribosomal RNA (rRNA) gene sequencing was used to profile stool microbial communities, and various multivariate analysis approaches were used to quantitate microbial composition, abundance, and diversity. The metagenomic content of samples was inferred from 16S rRNA gene

SUBMITTER: Labus JS 

PROVIDER: S-EPMC5410709 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature