Antigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike.

ABSTRACT: The extraordinary genetic diversity of the HIV-1 envelope spike [Env; trimeric (gp160)₃, cleaved to (gp120/gp41)₃] poses challenges for vaccine development. Envs of different clinical isolates exhibit different sensitivities to antibody-mediated neutralization. Envs of difficult-to-neutralize viruses are thought to be more stable and conformationally homogeneous trimers than those of easy-to-neutralize viruses, thereby providing more effective concealment of conserved, functionally critical sites. In this study we have characterized the antigenic properties of an Env derived from one of the most neutralization-resistant HIV-1 isolates, CH120.6. Sequence variation at neutralizing epitopes does not fully account for its exceptional resistance to antibodies. The full-len

SUBMITTER: Cai Y 

PROVIDER: S-EPMC5410843 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature