Calorically restricted diets decrease PCSK9 in overweight adolescents.

ABSTRACT:

Background and aims

Nutritional therapy is the first line approach to treatment of hyperlipidemia in childhood. Proprotein convertase subtilisin kexin type 9 (PCSK9) is a key regulator of plasma cholesterol levels and a target of novel lipid-lowering pharmacotherapies. We examined the effects of an intensive nutritional intervention on PCSK9 levels in overweight adolescents with cardiovascular disease (CVD) risk factors.

Methods and results

Twenty seven obese and overweight adolescents with CVD risk factors were assigned to either a low fat or low glycemic load diet. During an 8-week "Intensive Phase," assigned meals were delivered to the home, and all participants received weekly in-person home nutrition counseling and phone calls. The subjects then underwent a 4-month "Mai

SUBMITTER: Levenson AE 

PROVIDER: S-EPMC5410867 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature