Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex.

ABSTRACT: It is widely accepted that amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's disease. In addition, APP has been proposed to have functions in numerous biological processes including neuronal proliferation, differentiation, migration, axon guidance, and neurite outgrowth, as well as in synapse formation and function. However, germline knockout of APP yields relatively subtle phenotypes, and brain development appears grossly normal. This is thought to be due in part to functional compensation by APP family members and other type I transmembrane proteins. Here, we have generated a conditional mouse knockout for APP that is controlled temporally using Cre^ER and tamoxifen administration. We show that total cortical expression of APP is reduced fo

SUBMITTER: Callahan DG 

PROVIDER: S-EPMC5411011 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature