Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.

ABSTRACT:

Background

Vaso-occlusive episodes (VOEs) are a significant source of morbidity among children and adults with sickle cell disease (SCD). There is little information on methadone use for SCD pain. This investigation evaluated methadone pharmacokinetics in children and adults with SCD, with a secondary aim to assess pain relief and opioid consumption.

Procedure

Participants included children (<18 years) and adults with a VOE requiring hospitalization. Patients were randomly assigned to receive standard care (opioid patient-controlled analgesia; control group) or one dose of intravenous methadone (0.1-0.125 mg/kg) in addition to standard care (methadone group). Venous methadone and metabolite concentrations were measured. Pain scores, pain relief scores, and opioid consumption

SUBMITTER: Horst J 

PROVIDER: S-EPMC5411015 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature