Aberrant leukocyte telomere length in Birdshot Uveitis.

ABSTRACT:

Purpose

Birdshot Uveitis (BU) is an archetypical chronic inflammatory eye disease, with poor visual prognosis, that provides an excellent model for studying chronic inflammation. BU typically affects patients in the fifth decade of life. This suggests that it may represent an age-related chronic inflammatory disease, which has been linked to increased erosion of telomere length of leukocytes.

Methods

To study this in detail, we exploited a sensitive standardized quantitative real-time polymerase chain reaction to determine the peripheral blood leukocyte telomere length (LTL) in 91 genotyped Dutch BU patients and 150 unaffected Dutch controls.

Results

Although LTL erosion rates were very similar between BU patients and healthy controls, we observed that BU patients dis

SUBMITTER: Vazirpanah N 

PROVIDER: S-EPMC5411068 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature