Mn²⁺-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy.

ABSTRACT: Nanoparticle drug delivery carriers, which can implement high performances of multi-functions, are of great interest, especially for improving cancer therapy. Herein, we reported a new approach to construct Mn²⁺-coordinated doxorubicin (DOX)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles as a platform for synergistic chemo-photothermal tumor therapy. DOX-loaded PLGA (DOX/PLGA) nanoparticles were first synthesized through a double emulsion-solvent evaporation method, and then modified with polydopamine (PDA) through self-polymerization of dopamine, leading to the formation of PDA@DOX/PLGA nanoparticles. Mn²⁺ ions were then coordinated on the surfaces of PDA@DOX/PLGA to obtain Mn²⁺-PDA@DOX/PLGA nanoparticles. In our system, Mn²⁺-P

SUBMITTER: Xi J 

PROVIDER: S-EPMC5411169 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature