Association of Risk of Viremia, Immunosuppression, Serious Clinical Events, and Mortality With Increasing Age in Perinatally Human Immunodeficiency Virus-Infected Youth.

ABSTRACT:

Importance

As perinatally human immunodeficiency virus-infected youth (PHIVY) in the United States grow older and more treatment experienced, clinicians need updated information about the association of age, CD4 cell count, viral load (VL), and antiretroviral (ARV) drug use with risk of opportunistic infections, key clinical events, and mortality to understand patient risks and improve care.

Objective

To examine the incidence or first occurrence during follow-up of key clinical events (including Centers for Disease Control and Prevention stage B [CDC-B] and stage C [CDC-C] events) and mortality among PHIVY stratified by age, CD4 cell count, and VL and ARV status.

Design, setting, and participants

Combining data from the Pediatric HIV/AIDS Cohort Study (PHACS) Adolesce

SUBMITTER: Neilan AM 

PROVIDER: S-EPMC5411314 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature